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Comment
. 2015 Jun;38(6):331-2.
doi: 10.1016/j.tins.2015.04.006. Epub 2015 May 13.

Muddying the water in brain edema?

Alex J Smith  1 , Byung-Ju Jin  1 , Alan S Verkman  2
Affiliations
Comment

Muddying the water in brain edema?

Alex J Smith et al. Trends Neurosci. 2015 Jun.
No abstract available

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Figures

Figure 1
Figure 1
The glymphatic hypothesis versus conventional understanding of the role of aquaporin-4 (AQP4) in brain water movement. (A) The glymphatic hypothesis proposes a major role for hydrostatic pressure-driven water flow through astrocyte endfeet; conventionally, transmembrane flow in response to hydrostatic pressure is small compared with osmotic pressure gradients. (B) In the glymphatic model, water flows through endfeet through AQP4 to drive convection in the parenchyma; conventionally, water flow causes cell swelling (or shrinking) until osmotic equilibrium is reached. (C) In the glymphatic model, AQP4-facilitated convective water flow drives directional movement of large solutes; conventionally, AQP4 regulates diffusion through effects on extracellular space (ECS) volume.
See this image and copyright information in PMC

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References

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