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Clinical Trial
. 2015 Aug;149(2):330-9.
doi: 10.1053/j.gastro.2015.05.007. Epub 2015 May 14.

Delayed Gastric Emptying Is Associated With Early and Long-term Hyperglycemia in Type 1 Diabetes Mellitus

Adil E Bharucha  1 , Barbara Batey-Schaefer  2 , Patricia A Cleary  3 , Joseph A Murray  4 , Catherine Cowie  5 , Gayle Lorenzi  6 , Marsha Driscoll  7 , Judy Harth  7 , Mary Larkin  8 , Marielle Christofi  8 , Margaret Bayless  9 , Nyra Wimmergren  10 , William Herman  11 , Fred Whitehouse  12 , Kim Jones  12 , Davida Kruger  12 , Cathy Martin  11 , Georgia Ziegler  13 , Alan R Zinsmeister  14 , David M Nathan  8 ; Diabetes Control and Complications Trial–Epidemiology of Diabetes Interventions and Complications Research Group
Affiliations
Clinical Trial

Delayed Gastric Emptying Is Associated With Early and Long-term Hyperglycemia in Type 1 Diabetes Mellitus

Adil E Bharucha et al. Gastroenterology. 2015 Aug.

Abstract

Background & aims: After the Diabetes Control and Complications Trial (DCCT), the Epidemiology of Diabetes Interventions and Complications (EDIC) study continued to show persistent benefit of prior intensive therapy on neuropathy, retinopathy, and nephropathy in type 1 diabetes mellitus (DM). The relationship between control of glycemia and gastric emptying (GE) is unclear.

Methods: We assessed GE with a (13)C-spirulina breath test and symptoms in 78 participants with type 1 diabetes at year 20 of EDIC. The relationship between delayed GE and glycated hemoglobin (HbA1c), complications of DM, and gastrointestinal symptoms were evaluated.

Results: GE was normal (37 participants; 50%), delayed (35 participants; 47%), or rapid (2 participants; 3%). The latest mean HbA1c was 7.7%. In univariate analyses, delayed GE was associated with greater DCCT baseline HbA1c and duration of DM before DCCT (P ≤ .04), greater mean HbA1c over an average of 27 years of follow-up evaluation (during DCCT-EDIC, P = .01), lower R-R variability during deep breathing (P = .03) and severe nephropathy (P = .05), and a greater composite upper gastrointestinal symptom score (P < .05). In multivariate models, retinopathy was the only complication of DM associated with delayed GE. Separately, DCCT baseline HbA1c (odds ratio [OR], 1.6; 95% confidence interval [CI], 1.1-2.3) and duration of DM (OR, 1.2; 95% CI, 1.01-1.3) before DCCT entry and mean HbA1c during DCCT-EDIC (OR, 2.2; 95% CI, 1.04-4.5) were associated independently with delayed GE.

Conclusions: In the DCCT/EDIC study, delayed GE was remarkably common and associated with gastrointestinal symptoms and with measures of early and long-term hyperglycemia. ClinicalTrials.gov numbers NCT00360815 and NCT00360893.

Keywords: Diabetic Gastroparesis; Glycemic Control; HbA1c; Neuropathy.

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Figures

Figure 1
Figure 1
Relationship between HbA1c at DCCT entry and gastric emptying T ½. The rectangle shows the normal range for GE T½.
See this image and copyright information in PMC

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