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Case Reports
. 2015 Jul;27(1):154-5.
doi: 10.1016/j.intimp.2015.05.007. Epub 2015 May 14.

A case of pediatric Steven-Johnson Syndrome associated with albuterol consumption

Valentina Maggini  1 , Niccolò Lombardi  1 , Maria Carmela Lenti  1 , Stefano Masi  2 , Sandra Trapani  3 , Alessandra Pugi  4 , Alessandro Mugelli  1 , Alfredo Vannacci  1
Affiliations
Case Reports

A case of pediatric Steven-Johnson Syndrome associated with albuterol consumption

Valentina Maggini et al. Int Immunopharmacol. 2015 Jul.

Abstract

We describe a case of Steven-Johnson Syndrome (SJS) associated with albuterol exposure in a 6-year-old male. A possible contributing role of albuterol in SJS occurrence in the present case is strongly suggested by the temporal relationship between the event and the initiation of drug therapy as well as by the positive rechallenge. To the best of our knowledge, albuterol had not been previously associated with SJS in medical literature. It can be therefore possible that physicians, pediatricians in particular, probably not aware of the possible risk of albuterol-induced SJS, might underestimate skin reactions in children taking the drug, thus underreporting this kind of severe adverse drug reaction.

Keywords: Albuterol; Asthma; Emergency department; Pediatrics; Pharmacovigilance; Steven–Johnson Syndrome.

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