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Randomized Controlled Trial
. 2015 Jul 1:152:157-63.
doi: 10.1016/j.drugalcdep.2015.04.004. Epub 2015 Apr 27.

Alexithymia level and response to computer-based training in cognitive behavioral therapy among cocaine-dependent methadone maintained individuals

Kristen P Morie  1 , Charla Nich  2 , Karen Hunkele  2 , Marc N Potenza  2 , Kathleen M Carroll  2
Affiliations
Randomized Controlled Trial

Alexithymia level and response to computer-based training in cognitive behavioral therapy among cocaine-dependent methadone maintained individuals

Kristen P Morie et al. Drug Alcohol Depend. .

Abstract

Background: Alexithymia, a characteristic marked by poor ability to identify, define and communicate emotions, has been associated with poorer treatment outcome, including traditional clinician delivered CBT. Computerized cognitive behavioral therapy (CBT4CBT), an effective adjunct to treatment, may provide a means of conveying skills without requiring interaction with a clinician.

Methods: Seventy-three methadone maintained, cocaine dependent individuals participating in an 8-week randomized clinical trial comparing standard methadone maintenance to methadone maintenance plus CBT4CBT completed the Toronto Alexithymia Scale (TAS-20) at pretreatment, post-treatment, and follow-ups conducted one, two, and 6 months after treatment.

Results: There were no statistically significant differences on baseline TAS-20 scores by multiple demographic and substance use variables including gender and substance use severity. Higher TAS-20 scores were associated with somewhat higher levels of distress as measured by the Beck Depression Inventory and multiple Brief Severity Index scales. TAS-20 scores remained relatively stable throughout the duration of treatment and follow-up. Indicators of treatment process, including treatment retention, adherence and therapeutic alliance, were not significantly correlated with TAS-20 scores. There was a significant interaction of alexithymia and treatment condition, such that individuals with higher baseline scores on the TAS-20 submitted significantly higher percentages of cocaine-negative urine toxicology specimens and reported a higher percentage of abstinence days, and longer periods of consecutive abstinence within treatment when assigned to CBT4CBT compared with treatment as usual.

Conclusions: These findings suggest that individuals with increased alexithymia may benefit from computerized CBT; possibly via reduced demands on interpersonal skills and interactions associated with computerized therapies.

Trial registration: ClinicalTrials.gov NCT00350610.

Keywords: Alexithymia; Cognitive behavioral therapy; Web based therapies.

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Figures

Figure 1
Figure 1
Interaction of TAS-20 score by treatment group; percent of cocaine-negative urine toxicology screens within treatment; results of ATI analyses
Figure 2
Figure 2
Frequency of cocaine use by time, TAS-20 alexithymia score (using cut-off of 61), and treatment condition (CBT4CBT (computerized CBT plus TAU versus TAU (treatment as usual) alone).
See this image and copyright information in PMC

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