Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2015 Dec;76(2):152-155.
doi: 10.1016/j.cyto.2015.04.019. Epub 2015 May 14.

Correlation of Interleukin-6 levels and lectins during Schistosoma haematobium infection

Justin S Antony  1 , Olusola Ojurongbe  2 , Christian G Meyer  3 , Kumarasamy Thangaraj  4 , Anshuman Mishra  4 , Peter G Kremsner  1 , Thirumalaisamy P Velavan  5
Affiliations

Correlation of Interleukin-6 levels and lectins during Schistosoma haematobium infection

Justin S Antony et al. Cytokine. 2015 Dec.

Abstract

Urogenital schistosomiasis caused by Schistosoma haematobium induces a Th2 immune response, including expression of Interleukin-6. IL-6 confers protection from experimental Schistosoma-induced pulmonary hypertension and modulates production of mannose-binding lectin (MBL) and other lectins. We studied IL-6 levels in schistosomiasis and its effect on lectins production. Elevated IL-6 levels occurred in cases, compared to controls. IL-6 correlated with the lectins MBL, ficolin-2 and Collectin Kidney-1 (CL-K1) in cases, but correlated inversely in controls. The study shows that IL-6 levels are elevated in individuals infected with urogenital schistosomiasis. IL-6 was also found to be correlated with the production of lectins in S. haematobium infection. A similar correlation between IL-6 and MBL was observed during visceral leishmaniasis.

Keywords: CL-K1; Ficolin-2; IL-6; MBL; Schistosomiasis.

PubMed Disclaimer

Publication types

MeSH terms

LinkOut - more resources