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. 2015 May 16:13:33.
doi: 10.1186/s12915-015-0140-6.

Q&A: insulin secretion and type 2 diabetes: why do β-cells fail?

James Cantley  1 , Frances M Ashcroft  2
Affiliations

Q&A: insulin secretion and type 2 diabetes: why do β-cells fail?

James Cantley et al. BMC Biol. .

Erratum in

No abstract available

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Figures

Fig. 1
Fig. 1
Glucose homeostasis. A rise in blood glucose triggers insulin secretion from β-cells (blue) within the pancreatic islets. Insulin lowers blood glucose by acting on target tissues, suppressing glucose output from the liver and stimulating glucose uptake into muscle and fat. α-cells (yellow) are the glucagon-secreting cells of the pancreas; δ-cells (green) secrete somatostatin
Fig. 2
Fig. 2
Glucose-stimulated insulin secretion. At basal levels of blood glucose (left-hand panel), the ATP-sensitive K+ channels (KATP channels) in pancreatic β-cells remain open, maintaining membrane hyperpolarization, Ca2+ channel closure and inhibiting insulin secretion. A rise in blood glucose (right-hand panel) drives oxidative phosphorylation and ATP production, resulting in the closure of KATP channels, plasma membrane depolarization, calcium influx and insulin vesicle exocytosis
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References

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