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. 2015;9(5):433-41.
doi: 10.2217/bmm.15.12.

Prognostic value of sST2 and galectin-3 for death relative to renal function in patients hospitalized for heart failure

Rongcheng Zhang, Yuhui Zhang, Tao An, Xiao Guo, Shijie Yin, Yunhong Wang, James L Januzzi  1 , Thomas P Cappola  2 , Jian Zhang
Affiliations

Prognostic value of sST2 and galectin-3 for death relative to renal function in patients hospitalized for heart failure

Rongcheng Zhang et al. Biomark Med. 2015.

Abstract

Aim: To evaluate the associations of soluble ST2 (sST2) and galectin-3 with death relative to renal function in patients with heart failure (HF).

Methods: Eleven-hundred-and-sixty-one patients hospitalized for HF with 1-year follow up were enrolled for biomarkers analysis.

Results: Patients were divided into two groups based on eGFR of either > or ≤60 ml/min/1.73 m(2). sST2 was independently associated with death in both categories of renal function, while galectin-3 lost this significance after addition of NT-proBNP to the model of patients with eGFR ≤60 ml/min/1.73 m(2).

Conclusion: In patients with HF, sST2 improved prediction for death beyond risk factors without being influenced by renal function, however, the prognostic value of galectin-3 is less clear below an eGFR of 60 ml/min/1.73 m(2).

Keywords: NT-proBNP; biomarker; cardiac remodeling; death; eGFR; galectin-3; heart failure; prognosis; renal function; sST2.

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