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. 2015 Jun;36(6):671-7.
doi: 10.15537/smj.2015.6.10697.

Association of total antioxidants level with glaucoma type and severity

Ahmed Mousa  1 , Altaf A Kondkar, Saleh A Al-Obeidan, Taif A Azad, Tahira Sultan, Essam Osman, Khaled K Abu-Amero
Affiliations

Association of total antioxidants level with glaucoma type and severity

Ahmed Mousa et al. Saudi Med J. 2015 Jun.

Abstract

Objectives: To compare the mean total antioxidant status (TAS) among 3 glaucoma types, namely: pseudoexfoliation glaucoma (PEG), primary open angle glaucoma (POAG), and primary angle closure glaucoma (PACG), and study its potential association with various clinical glaucoma-parameters.

Methods: In this case-control study, plasma samples were obtained between September 2013 and October 2014 from 340 glaucoma patients (PEG [n=54]; POAG [n=147]; PACG [n=139]), and 351 controls of matching age, gender, ethnicity, and 5 different systemic co-morbidities from King Abdulaziz University Hospital, Riyadh, Saudi Arabia. The TAS in all samples was determined by a colorimetric-based assay.

Results: The mean±standard deviation of TAS was significantly lower among cases: 0.77±0.32 than controls: 1.1±0.22, p less than 0.0001. Moreover, the TAS levels were significantly different across the 3 types of glaucoma: 0.86±0.24 in PEG, 0.47±0.32 in POAG, and 0.98±0.41 in PACG (all p less than 0.0001). In addition, there was a significant correlation between TAS and age at onset (Pearson correlation coefficient [R] 0.17, p less than 0.0001), cup/disc ratio (R: -0.13, p=0.004), and number of anti-glaucoma medications (R: -0.16, p=0.001).

Conclusion: Our findings provide evidence that plasma TAS levels are decreased in patients with glaucoma, more so in POAG and PEG than PACG, supporting the hypothesis that decreased antioxidative defense and/or increased oxidative stress may have a critical role in the pathogenesis of glaucoma.

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Figures

Figure 1
Figure 1
Mean ± standard deviation of total antioxidant concentration for different types of glaucoma. PEG - pseudoexfoliation glaucoma, POAG - primary open angle glaucoma, PACG - primary angle closure glaucoma, TAS - total antioxidant status
See this image and copyright information in PMC

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