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Review
. 2015 Oct:272:97-108.
doi: 10.1016/j.expneurol.2015.05.006. Epub 2015 May 15.

Models and mechanisms of vascular dementia

Poornima Venkat  1 , Michael Chopp  2 , Jieli Chen  3
Affiliations
Review

Models and mechanisms of vascular dementia

Poornima Venkat et al. Exp Neurol. 2015 Oct.

Abstract

Vascular dementia (VaD) is the second leading form of dementia after Alzheimer's disease (AD) plaguing the elderly population. VaD is a progressive disease caused by reduced blood flow to the brain, and it affects cognitive abilities especially executive functioning. VaD is poorly understood and lacks suitable animal models, which constrain the progress on understanding the basis of the disease and developing treatments. This review article discusses VaD, its risk factors, induced cognitive disability, various animal (rodent) models of VaD, pathology, and mechanisms of VaD and treatment options.

Keywords: Cognition; High fat diet; Multiple infarct dementia; Treatment; Vascular dementia.

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Figures

Figure 1
Figure 1
Summarizes the risk factors, subtypes and characteristic features of VaD.
Figure 2
Figure 2
Summarizes the various cognitive disabilities of VaD patients and associated brain damage.
Figure 3
Figure 3
Summarizes the various mechanism implicated in the pathogenesis of VaD.
See this image and copyright information in PMC

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