Dramatic response to selective internal radiation therapy for unresectable hepatocellular carcinoma

Woo Daniel Park¹, Bob T Li², Richard Maher³, Jaswinder S Samra⁴, Stephen Clarke⁵, Elizabeth J Bernard⁶, Dale L Bailey⁷, Nick Pavlakis⁵

Affiliations

¹ Department of Medical Oncology , Royal North Shore Hospital, St Leonards , Sydney, NSW , Australia.
² Department of Medicine, Division of Solid Tumor Oncology , Memorial Sloan Kettering Cancer Center , New York, NY , USA ; Sydney Medical School , University of Sydney , Sydney, NSW , Australia.
³ Department of Radiology , Royal North Shore Hospital , Sydney, NSW , Australia.
⁴ Sydney Medical School , University of Sydney , Sydney, NSW , Australia ; Department of Gastrointestinal Surgery , Royal North Shore Hospital, St Leonards , Sydney, NSW , Australia ; Australian School of Advanced Medicine , Macquarie University, North Ryde , Sydney, NSW , Australia.
⁵ Department of Medical Oncology , Royal North Shore Hospital, St Leonards , Sydney, NSW , Australia ; Sydney Medical School , University of Sydney , Sydney, NSW , Australia.
⁶ Sydney Medical School , University of Sydney , Sydney, NSW , Australia ; Department of Nuclear Medicine , Royal North Shore Hospital , Sydney, NSW , Australia.
⁷ Department of Nuclear Medicine , Royal North Shore Hospital , Sydney, NSW , Australia ; Faculty of Health Sciences , University of Sydney , Sydney, NSW , Australia.

PMID: 25988077
PMCID: PMC4370010
DOI: 10.1093/omcr/omv007

Dramatic response to selective internal radiation therapy for unresectable hepatocellular carcinoma

Woo Daniel Park et al. Oxf Med Case Reports. 2015.

. 2015 Feb 20;2015(2):194-5.

doi: 10.1093/omcr/omv007. eCollection 2015 Feb.

Authors

Woo Daniel Park¹, Bob T Li², Richard Maher³, Jaswinder S Samra⁴, Stephen Clarke⁵, Elizabeth J Bernard⁶, Dale L Bailey⁷, Nick Pavlakis⁵

Affiliations

¹ Department of Medical Oncology , Royal North Shore Hospital, St Leonards , Sydney, NSW , Australia.
² Department of Medicine, Division of Solid Tumor Oncology , Memorial Sloan Kettering Cancer Center , New York, NY , USA ; Sydney Medical School , University of Sydney , Sydney, NSW , Australia.
³ Department of Radiology , Royal North Shore Hospital , Sydney, NSW , Australia.
⁴ Sydney Medical School , University of Sydney , Sydney, NSW , Australia ; Department of Gastrointestinal Surgery , Royal North Shore Hospital, St Leonards , Sydney, NSW , Australia ; Australian School of Advanced Medicine , Macquarie University, North Ryde , Sydney, NSW , Australia.
⁵ Department of Medical Oncology , Royal North Shore Hospital, St Leonards , Sydney, NSW , Australia ; Sydney Medical School , University of Sydney , Sydney, NSW , Australia.
⁶ Sydney Medical School , University of Sydney , Sydney, NSW , Australia ; Department of Nuclear Medicine , Royal North Shore Hospital , Sydney, NSW , Australia.
⁷ Department of Nuclear Medicine , Royal North Shore Hospital , Sydney, NSW , Australia ; Faculty of Health Sciences , University of Sydney , Sydney, NSW , Australia.

PMID: 25988077
PMCID: PMC4370010
DOI: 10.1093/omcr/omv007

Abstract

A 54-year-old woman with a known history of multifocal hepatocellular carcinoma was treated with selective internal radiation therapy (SIRT) using yttrium-90 ((90)Y) microspheres, despite disease relapses after surgical resection and transarterial chemoembolization. She developed a dramatic clinical, radiological and metabolic response after 9 weeks. This case provides visual illustration of the potential roles of SIRT in the treatment of hepatocellular carcinoma.

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Figures

**Figure 1:**
(a) FDG-PET/CT with axial views showing recurrent multifocal hepatocellular carcinoma and perfusion of injected ⁹⁰Y-tagged resin microspheres. (b) Follow-up FDG-PET/CT at 9 weeks after injection of ⁹⁰Y microspheres showing a radiological response with tumour necrosis and a near complete metabolic response.

See this image and copyright information in PMC

References

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Dramatic response to selective internal radiation therapy for unresectable hepatocellular carcinoma

Affiliations

Dramatic response to selective internal radiation therapy for unresectable hepatocellular carcinoma

Authors

Affiliations

Abstract

Figures

References

Grants and funding

LinkOut - more resources

Full Text Sources

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