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Comment
. 2015 May 21;17(1):68.
doi: 10.1186/s13058-015-0573-4.

Anti-CCL2: building a reservoir or opening the floodgates to metastasis?

Jessica R Hitchcock  1 , Christine J Watson  2
Affiliations
Comment

Anti-CCL2: building a reservoir or opening the floodgates to metastasis?

Jessica R Hitchcock et al. Breast Cancer Res. .

Abstract

Neutralisation of macrophage chemoattractant C-C chemokine ligand 2 (CCL2) has shown reduced metastasis and enhanced survival in numerous experimental models of tumorigenesis. However, important new findings reported in Nature by Momo Bentires-Alj's laboratory demonstrate that withdrawal of anti-CCL2 treatment accelerates lung metastasis and death in mice. The study highlights the need to consider longer term consequences of therapeutic intervention of metastatic disease, especially with regard to transient interference with the tumour microenvironment.

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References

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