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. 1989 Dec 1;45(11-12):1061-5.
doi: 10.1007/BF01950159.

Solid state fermentation for cephalosporin production by Streptomyces clavuligerus and Cephalosporium acremonium

M F Jermini  1 , A L Demain
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Solid state fermentation for cephalosporin production by Streptomyces clavuligerus and Cephalosporium acremonium

M F Jermini et al. Experientia. .

Abstract

Solid state fermentation systems were developed for the production of cephalosporins with Streptomyces clavuligerus and Cephalosporium acremonium. S. clavuligerus NRRL 3585 was grown on moistened barley under optimum solid state fermentation conditions for 7 days; approximately 300 micrograms cephalosporins per g substrate were extracted from the kernels. C. acremonium C-10 produced approximately 950 micrograms cephalosporin C per g substrate after 10 days of solid state fermentation.

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