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Case Reports
. 2013 Apr;17(2):218-21.
doi: 10.7162/S1809-97772013000200017.

Chondro-osseous respiratory epithelial adenomatoid hamartoma of the nasal cavity

Faysal Fedda  1 , Fouad Boulos  2 , Alain Sabri  3
Affiliations
Case Reports

Chondro-osseous respiratory epithelial adenomatoid hamartoma of the nasal cavity

Faysal Fedda et al. Int Arch Otorhinolaryngol. 2013 Apr.

Abstract

Introduction: Chondro-osseous respiratory epithelial adenomatoid hamartoma (COREAH) is a benign lesion of the nose and sinuses that is extremely rare, with only 2 cases reported in the literature to date.

Case report: We present herein the third reported case of COREAH, in a 38-year-old woman who presented with left nasal obstruction and a mass in her left nasal cavity. The mass was completely resected endoscopically. Microscopic examination showed hamartomatous proliferation of respiratory-type glands with mucinous metaplasia admixed with numerous spicules of mature bone, characteristic of COREAH.

Conclusion: COREAH is a benign hamartomatous proliferation of respiratory epithelium, submucosal glands, and chondro-osseous mesenchyme. The clinical differential diagnoses for such lesions include glandular hamartoma, inflammatory polyp, inverted papilloma, and low-grade sinonasal adenocarcinoma. Recognition of this lesion as benign despite its potentially worrisome radiographic appearance is important to avoid an unnecessarily radical surgical procedure.

Keywords: hamartoma; nasal cavity; nasal polyps.

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Figures

Figure 1.
Figure 1.
Axial computed tomography (CT) image of a left nasal chondro-osseous respiratory epithelial adenomatoid hamartoma (COREAH) showing a large (4 × 2.4 × 1.1 cm), iso-intense mass with focal enhancement (arrowhead) causing mild deviation of the nasal septum to the right with no erosion of the bone.
Figure 2.
Figure 2.
A. COREAH. Submucosal glandular proliferation originating from surface respiratory epithelium-lined mucosa, hypocellular fibromyxoid stroma, and mature bone. (Hematoxylin & eosin, 20x) B. COREAH. Mucinous metaplasia and mature bone trabeculae (osseous metaplasia). (Hematoxylin & eosin, 100x)
See this image and copyright information in PMC

References

    1. Kumar V Abbas A K Fausto N Neoplasia Philadelphia, PA: Elsevier-Saunders Publishing Company; 2005. 272 p
    1. Wenig B M, Heffner D K. Respiratory epithelial adenomatoid hamartomas of the sinonasal tract and nasopharynx: a clinicopathologic study of 31 cases. Ann Otol Rhinol Laryngol. 1995;104:639–45. - PubMed
    1. Graeme-Cook F, Pilch B Z. Hamartomas of the nose and nasopharynx. Head Neck. 1992;14:321–27. - PubMed
    1. Adair C F, Thompson L DR, Wenig B M, Heffner D K. Chondoosseeous and respiratory epithelial hamartomas of the sinonasal tract and nasopharynx, Mod. Pathol. 1996;9(1):100.
    1. Roffman E, Baredes S, Mirani N. Respiratory epithelial adenomatoid hamartomas and chondro-osseous respiratory epithelial adenomatoid hamartomas of the sinonasal tract: a case series and literature review. Am J Rhinol. 2006;20:596–90. - PubMed

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