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. 2015 May 20;13(5):e1002151.
doi: 10.1371/journal.pbio.1002151. eCollection 2015 May.

Applying the ARRIVE Guidelines to an In Vivo Database

Natasha A Karp  1 , Terry F Meehan  2 , Hugh Morgan  3 , Jeremy C Mason  2 , Andrew Blake  3 , Natalja Kurbatova  2 , Damian Smedley  1 , Julius Jacobsen  1 , Richard F Mott  4 , Vivek Iyer  5 , Peter Matthews  5 , David G Melvin  1 , Sara Wells  3 , Ann M Flenniken  6 , Hiroshi Masuya  7 , Shigeharu Wakana  7 , Jacqueline K White  8 , K C Kent Lloyd  9 , Corey L Reynolds  10 , Richard Paylor  11 , David B West  12 , Karen L Svenson  13 , Elissa J Chesler  13 , Martin Hrabě de Angelis  14 , Glauco P Tocchini-Valentini  15 , Tania Sorg  16 , Yann Herault  16 , Helen Parkinson  2 , Ann-Marie Mallon  3 , Steve D M Brown  3
Affiliations

Applying the ARRIVE Guidelines to an In Vivo Database

Natasha A Karp et al. PLoS Biol. .

Abstract

The Animal Research: Reporting of In Vivo Experiments (ARRIVE) guidelines were developed to address the lack of reproducibility in biomedical animal studies and improve the communication of research findings. While intended to guide the preparation of peer-reviewed manuscripts, the principles of transparent reporting are also fundamental for in vivo databases. Here, we describe the benefits and challenges of applying the guidelines for the International Mouse Phenotyping Consortium (IMPC), whose goal is to produce and phenotype 20,000 knockout mouse strains in a reproducible manner across ten research centres. In addition to ensuring the transparency and reproducibility of the IMPC, the solutions to the challenges of applying the ARRIVE guidelines in the context of IMPC will provide a resource to help guide similar initiatives in the future.

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Conflict of interest statement

The authors have declared that no competing interests exist.

Figures

Fig 1
Fig 1. A summary of the areas encompassed by the ARRIVE guidelines.
The ARRIVE guidelines are organised into twenty sections, which cover all areas of a typical research manuscript. Image credit: NC3Rs: https://www.nc3rs.org.uk/arrive-guidelines.
See this image and copyright information in PMC

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