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Case Reports
. 2015 May 20:16:300-4.
doi: 10.12659/AJCR.893570.

Leiomyomatosis peritonealis disseminata positive for progesterone receptor

Takashi Yuri  1 , Yuichi Kinoshita  1 , Michiko Yuki  1 , Katsuhiko Yoshizawa  1 , Yuko Emoto  1 , Airo Tsubura  1
Affiliations
Case Reports

Leiomyomatosis peritonealis disseminata positive for progesterone receptor

Takashi Yuri et al. Am J Case Rep. .

Abstract

Background: Leiomyomatosis peritonealis disseminata (LPD) is a rare condition that occurs in reproductive-age women. The pathogenesis of LPD is considered to be related to female sex hormones.

Case report: A 30-year-old woman who had undergone an ovariectomy due to calcified thecoma at 24 years of age and had delivered a baby boy at 29 years of age showed abnormal abdominal-pelvic masses in a computed tomography scan. The peritoneal nodules were resected and histologically diagnosed as LPD. Smooth muscle cells in LPD lesions expressed progesterone receptor, while estrogen receptor and luteinizing hormone/chorionic gonadotropin receptor were negative.

Conclusions: LPD should be considered when multiple nodules mimicking dissemination of malignancies are found in the abdominal cavity. In the present case, progesterone may have been involved in the pathogenesis of LPD.

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Figures

Figure 1.
Figure 1.
(A) Cut surface of calcified thecoma. (B) Calcified thecoma. Hematoxylin and eosin (20×). (C) Calcified thecoma. Fatty droplets were seen in vacuolated cells. Sudan III (40×).
Figure 2.
Figure 2.
Abdominal CT scan showing intraperitoneal nodules. Arrow in the picture indicates the largest mass in the mesentery of transverse colon.
Figure 3.
Figure 3.
Macroscopic, histologic and immunohistochemical findings of leiomyomatosis peritonealis disseminata (LPD). (A) Cut surface of the largest nodule seen in transverse mesocolon. (B) LPD is composed of monomorphic spindle cells. Hematoxylin and eosin (20×). (C) Spindle cells are positive for desmin (20×). (D) Spindle cells are focally positive for progesterone receptor (20×).
See this image and copyright information in PMC

References

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