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Comment
. 2015 May 19;42(5):779-81.
doi: 10.1016/j.immuni.2015.05.002.

IL-2: Change Structure … Change Function

Jeffrey A Bluestone  1 , Natasha Crellin  2 , Eleonora Trotta  3
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IL-2: Change Structure … Change Function

Jeffrey A Bluestone et al. Immunity. .
Free article

Abstract

In this issue of Immunity, Spangler et al. and Mitra et al. demonstrate how structural changes in the IL-2 molecule alter interactions with the IL-2 receptor, leading to differential cellular targeting and biochemical responses and selective immune consequences.

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