Germinal center quality control: death by Fas
- PMID: 25992852
- DOI: 10.1016/j.immuni.2015.05.005
Germinal center quality control: death by Fas
Abstract
Fas is a cell surface death receptor critical for immune regulation. In this issue of Immunity, Butt et al. (2015) show that Fas eliminates B cells that have become uncoupled from positive and negative selection in the germinal center.
Copyright © 2015 Elsevier Inc. All rights reserved.
Comment on
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FAS Inactivation Releases Unconventional Germinal Center B Cells that Escape Antigen Control and Drive IgE and Autoantibody Production.Immunity. 2015 May 19;42(5):890-902. doi: 10.1016/j.immuni.2015.04.010. Epub 2015 May 12. Immunity. 2015. PMID: 25979420
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