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. 2016 Jun;221(5):2695-701.
doi: 10.1007/s00429-015-1065-0. Epub 2015 May 21.

Homotopic reciprocal functional connectivity between anterior human insulae

Nuria Lacuey  1 , Bilal Zonjy  2 , Emine S Kahriman  2 , Ahmad Marashly  2 , Jonathan Miller  2 , Samden D Lhatoo  2 , Hans O Lüders  2
Affiliations

Homotopic reciprocal functional connectivity between anterior human insulae

Nuria Lacuey et al. Brain Struct Funct. 2016 Jun.

Abstract

The aim of this study was to investigate functional connectivity between right and left insulae in the human brain. We studied a patient with implanted depth electrodes for epilepsy surgery evaluation with stereotactically placed symmetric depth electrodes in both insulae. Bipolar 1 Hz electrical stimulation of the right and left posterior short gyri in the anterior insula evoked responses in the contralateral insular structures. These responses showed a latency of 8-24 ms. This report demonstrates for the first time bi-directional homotopic and heterotopic functional connectivity between right and left anterior insulae. The short latency of the evoked responses suggests mono- or oligo-synaptic connections, most likely via the corpus callosum.

Keywords: CCEP; Corpus callosum; Epilepsy; Evoked potentials; Functional connectivity; Insula.

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