Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Case Reports
. 2015 May 20:2015:bcr2015209396.
doi: 10.1136/bcr-2015-209396.

Breast cancer in male-to-female (MtF) transgender patients: is hormone receptor negativity a feature?

Zhi Hao Teoh  1 , David Archampong  2 , Tim Gate  2
Affiliations
Case Reports

Breast cancer in male-to-female (MtF) transgender patients: is hormone receptor negativity a feature?

Zhi Hao Teoh et al. BMJ Case Rep. .

Abstract

A 41-year-old male-to-female (MtF) transgender patient presented with a symptomatic tender lump in the left breast. There was no family history of breast cancer. She had been receiving estrogen therapy for 14 years to maintain her secondary sexual characteristics. Triple assessment revealed a 13 mm triple-negative grade 3 invasive ductal carcinoma. The tumour was completely excised following a left wide local excision and sentinel lymph node biopsy. There was no regional lymph node involvement. She was referred to the oncologist for adjuvant chemotherapy and radiotherapy.

PubMed Disclaimer

Figures

Figure 1
Figure 1
Grade 3 invasive ductal carcinoma (H&E stain ×100).
See this image and copyright information in PMC

References

    1. Cancer Research UK. Breast cancer incidence in males. http://www.cancerresearchuk.org/cancer-info/cancerstats/types/breast/inc... (accessed 12 Dec 2014).
    1. Symmers WS. Carcinoma of breast in trans-sexual individuals after surgical and hormonal interference with the primary and secondary sex characteristics. BMJ 1968;2:83–5. 10.1136/bmj.2.5597.83 - DOI - PMC - PubMed
    1. Pritchard TJ, Pankowsky DA, Crowe JP et al. . Breast cancer in a male-to-female transsexual: a case report. JAMA 1988;259:2278–80. 10.1001/jama.1988.03720150054036 - DOI - PubMed
    1. Ganly I, Taylor EW. Breast cancer in a trans-sexual man receiving hormone replacement therapy. Br J Surg 1995;82:341 10.1002/bjs.1800820319 - DOI - PubMed
    1. Grabellus F, Worm K, Willruth A et al. . ETV6-NTRK3 gene fusion in a secretory carcinoma of the breast of a male-to-female transsexual. Breast 2005;14:71–4. 10.1016/j.breast.2004.04.005 - DOI - PubMed

Publication types