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Review
. 2016 Apr;38 Suppl 1(Suppl 1):E2250-8.
doi: 10.1002/hed.24132. Epub 2015 Aug 13.

Getting personal: Head and neck cancer management in the era of genomic medicine

Andrew C Birkeland  1 , Wendy R Uhlmann  2   3   4 , J Chad Brenner  1   5 , Andrew G Shuman  1   4   5
Affiliations
Review

Getting personal: Head and neck cancer management in the era of genomic medicine

Andrew C Birkeland et al. Head Neck. 2016 Apr.

Abstract

Background: Genetic testing is rapidly becoming an important tool in the management of patients with head and neck cancer. As we enter the era of genomics and personalized medicine, providers should be aware of testing options, counseling resources, and the benefits, limitations, and future of personalized therapy.

Methods: This article offers a primer to assist clinicians treating patients in anticipating and managing the inherent practical and ethical challenges of cancer care in the genomic era.

Results: Clinical applications of genomics for head and neck cancer are emerging. We discuss the indications for genetic testing, types of testing available, implications for care, privacy/disclosure concerns, and ethical considerations. Hereditary genetic syndromes associated with head and neck neoplasms are reviewed, and online genetics resources are provided.

Conclusion: This article summarizes and contextualizes the evolving diagnostic and therapeutic options that impact the care of patients with head and neck cancer in the genomic era. © 2015 Wiley Periodicals, Inc. Head Neck 38: E2250-E2258, 2016.

Keywords: cancer; ethics; genomics; head and neck; personalized medicine.

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References

    1. Jemal A, Bray F, Center MM, Ferlay J, Ward E, Forman D. Global cancer statistics. CA Cancer J Clin. 2011;61(2):69–90. - PubMed
    1. Lacko M, Braakhuis BJ, Sturgis EM, et al. Genetic susceptibility to head and neck squamous cell carcinoma. Int J Radiat Oncol Biol Phys. 2014;89(1):38–48. - PubMed
    1. Stransky N, Egloff AM, Tward AD, et al. The mutational landscape of head and neck squamous cell carcinoma. Science. 2011;333(6046):1157–60. - PMC - PubMed
    1. Agrawal N, Frederick MJ, Pickering CR, et al. Exome sequencing of head and neck squamous cell carcinoma reveals inactivating mutations in NOTCH1. Science. 2011;333(6046):1154–7. - PMC - PubMed
    1. Cancer Genome Atlas Research Network. Comprehensive genomic characterization of head and neck squamous cell carcinomas. Nature. 2015;517(7536):576–82. - PMC - PubMed