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Comment
. 2015 Jul 15;21(14):3105-7.
doi: 10.1158/1078-0432.CCR-15-0458. Epub 2015 May 20.

Growth Factor Receptor Fusions Predict Therapeutic Sensitivity

Manmeet S Ahluwalia  1 , Jeremy N Rich  2
Affiliations
Comment

Growth Factor Receptor Fusions Predict Therapeutic Sensitivity

Manmeet S Ahluwalia et al. Clin Cancer Res. .

Abstract

Dysregulated growth factor pathways promote tumor growth in many cancers, but receptor-targeting strategies frequently offer limited benefit despite activation by receptor overexpression or amplification. In contrast, tumors harboring growth factor receptor fusions display exquisite dependence on receptor activity, providing predictive markers for patient response to inform precise oncology treatment.

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  • Detection, Characterization, and Inhibition of FGFR-TACC Fusions in IDH Wild-type Glioma.
    Di Stefano AL, Fucci A, Frattini V, Labussiere M, Mokhtari K, Zoppoli P, Marie Y, Bruno A, Boisselier B, Giry M, Savatovsky J, Touat M, Belaid H, Kamoun A, Idbaih A, Houillier C, Luo FR, Soria JC, Tabernero J, Eoli M, Paterra R, Yip S, Petrecca K, Chan JA, Finocchiaro G, Lasorella A, Sanson M, Iavarone A. Di Stefano AL, et al. Clin Cancer Res. 2015 Jul 15;21(14):3307-17. doi: 10.1158/1078-0432.CCR-14-2199. Epub 2015 Jan 21. Clin Cancer Res. 2015. PMID: 25609060 Free PMC article. Clinical Trial.

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