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Comment
. 2015 May 20;86(4):853-855.
doi: 10.1016/j.neuron.2015.05.014.

Using opioid receptors to expand the chemogenetic and optogenetic toolbox

Diane M Damez-Werno  1 , Paul J Kenny  2
Affiliations
Free article
Comment

Using opioid receptors to expand the chemogenetic and optogenetic toolbox

Diane M Damez-Werno et al. Neuron. .
Free article

Abstract

In this issue of Neuron, innovative new modifications to opioid receptors are used to expand the tools available to modulate neuronal activity. Vardy et al. (2015) describe a new "DREADD" chemogenetic tool based on the inhibitory κ opioid receptor (KORD) that can be used in conjunction with already-available DREADDs. Siuda et al. (2015) report the development of "opto-MOR," a light-activatable μ opioid receptor (MOR) chimera that can be used to better understand the complexities of MOR signaling.

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Comment on

  • A New DREADD Facilitates the Multiplexed Chemogenetic Interrogation of Behavior.
    Vardy E, Robinson JE, Li C, Olsen RHJ, DiBerto JF, Giguere PM, Sassano FM, Huang XP, Zhu H, Urban DJ, White KL, Rittiner JE, Crowley NA, Pleil KE, Mazzone CM, Mosier PD, Song J, Kash TL, Malanga CJ, Krashes MJ, Roth BL. Vardy E, et al. Neuron. 2015 May 20;86(4):936-946. doi: 10.1016/j.neuron.2015.03.065. Epub 2015 Apr 30. Neuron. 2015. PMID: 25937170 Free PMC article.
  • Spatiotemporal control of opioid signaling and behavior.
    Siuda ER, Copits BA, Schmidt MJ, Baird MA, Al-Hasani R, Planer WJ, Funderburk SC, McCall JG, Gereau RW 4th, Bruchas MR. Siuda ER, et al. Neuron. 2015 May 20;86(4):923-935. doi: 10.1016/j.neuron.2015.03.066. Epub 2015 Apr 30. Neuron. 2015. PMID: 25937173 Free PMC article.

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