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. 1989 Autumn;53(3):117-21.

Age-related changes in lipid peroxidation and protective enzymes in the central nervous system

K A Ansari  1 , E Kaplan, D Shoeman
Affiliations
  • PMID: 2599741

Age-related changes in lipid peroxidation and protective enzymes in the central nervous system

K A Ansari et al. Growth Dev Aging. 1989 Autumn.

Abstract

Brain homogenates were used to measure in vitro formation of thiobarbituric acid reactive substances (TBARS) in 5 CNS regions of 3, 12 and 22 month old male Fischer 344 rats. Glutathione peroxidase, catalase and superoxide dismutase activity in 105,000 x g supernatants of these homogenates was also measured. Results indicated that in vitro TBARS formation declined with age in all 5 areas studied. Glutathione peroxidase, catalase and superoxide dismutase activity did not change with age. Regional differences in the activity of glutathione peroxidase and catalase were noted.

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