Current radiosynthesis strategies for 5-HT2A receptor PET tracers
- PMID: 25997728
- DOI: 10.1002/jlcr.3288
Current radiosynthesis strategies for 5-HT2A receptor PET tracers
Abstract
Serotonin 2A receptors have been implicated in various psychophysiological functions and disorders such as depression, Alzheimer's disease, or schizophrenia. Therefore, neuroimaging of this specific receptor is of significant clinical interest, and it is not surprising that many attempts have been made to develop a suitable 5-HT2A R positron emission tomography-tracer. In this review, we give an overview on the precursor, reference compound synthesis, and the preparation of promising 5-HT2A R radiopharmaceuticals applied in positron emission tomography. We also highlight possible learning outcomes that can be made from these tracer development processes.
Keywords: (R)-[18F]MH.MZ; 5-HT2A; PET; [11C]Cimbi-36; [11C]MDL 100907; [18F]MDL 100907 [18F]altanserin; [18F]MH.MZ; [18F]RP62203; [18F]deuteroaltanserin; [18F]fananserin; tracer development.
Copyright © 2015 John Wiley & Sons, Ltd.
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