Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2015 Jun 15;58(7):265-73.
doi: 10.1002/jlcr.3288. Epub 2015 May 22.

Current radiosynthesis strategies for 5-HT2A receptor PET tracers

Affiliations
Review

Current radiosynthesis strategies for 5-HT2A receptor PET tracers

Matthias M Herth et al. J Labelled Comp Radiopharm. .

Abstract

Serotonin 2A receptors have been implicated in various psychophysiological functions and disorders such as depression, Alzheimer's disease, or schizophrenia. Therefore, neuroimaging of this specific receptor is of significant clinical interest, and it is not surprising that many attempts have been made to develop a suitable 5-HT2A R positron emission tomography-tracer. In this review, we give an overview on the precursor, reference compound synthesis, and the preparation of promising 5-HT2A R radiopharmaceuticals applied in positron emission tomography. We also highlight possible learning outcomes that can be made from these tracer development processes.

Keywords: (R)-[18F]MH.MZ; 5-HT2A; PET; [11C]Cimbi-36; [11C]MDL 100907; [18F]MDL 100907 [18F]altanserin; [18F]MH.MZ; [18F]RP62203; [18F]deuteroaltanserin; [18F]fananserin; tracer development.

PubMed Disclaimer

MeSH terms

Substances

LinkOut - more resources