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. 2015 Sep-Oct;19(5):525-8.
doi: 10.1016/j.bjid.2015.03.007. Epub 2015 May 18.

Hepatitis B virus genotyping in chronic hepatitis B patients in southwestern Saudi Arabia

Ahmed Morad Asaad  1 , Mohamed Saeed Zayed Al-Ayed  2 , Mohamed Aleraky  3 , Mohamed Ansar Qureshi  4
Affiliations

Hepatitis B virus genotyping in chronic hepatitis B patients in southwestern Saudi Arabia

Ahmed Morad Asaad et al. Braz J Infect Dis. 2015 Sep-Oct.

Abstract

The distribution of hepatitis B virus genotypes in Saudi Arabia is largely unknown. To the best of our knowledge there are no data available about HBV genotypes in southwestern region of the country. This study aimed to determine the epidemiologic distribution of hepatitis B virus genotypes in chronic hepatitis B patients in southwestern region, and to verify possible correlations between these genotypes and the clinical symptoms. A total of 160 patients with chronic hepatitis B infection were enrolled in this study. Sera were tested for liver function tests, hepatitis B virus markers and DNA load by standard procedures. HBV genotyping was performed by 2-tube nested PCR for determination of six genotypes (A-F). Genotype D was the most common, found in 135 (84.4%) patients, followed by A (18; 11.3%) and E (7; 4.3%). The rate of HBeAg positivity in genotype D patients was significantly lower compared with that in genotype A and E patients (p=0.01). There was no significant association between HBV genotypes and age, gender, liver function tests, or HBV DNA load. Genotypes D and E were predominant in chronic hepatitis B patients in southwestern Saudi Arabia. Awareness of hepatitis B virus serologic and genotypic patterns might help in the formulation of management plans, predicting clinical outcomes and updating prevention strategies.

Keywords: Genotype D; HBV genotypes; Hepatitis B; Najran.

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References

    1. World Health Organization . Sixty-Third World Health Assembly 2010; A63/15 Provisional Agenda Item 11.12. 2010. Viral hepatitis: report by the Secretariat.
    1. Ott J., Stevens G., Groeger J., et al. Global epidemiology of hepatitis B virus infection: new estimates of age-specific HBs Ag seroprevalence and endemicity. Vaccine. 2012;30:2212–2219. - PubMed
    1. Ministry of Health National Cancer Registry . National Cancer Registry; Riyadh: 2004. Cancer Incidence Report, Saudi Arabia 1999–2000; pp. 54–56.
    1. Algarni H.S., Memish Z.A., Assiri A.M., et al. Trends of reported cases of hepatitis B virus infection, Kingdom of Saudi Arabia, 2009–2013. Am J Res Commun. 2013 www.usa-journals.com
    1. Shi W., Zhang Z., Ling C., et al. Hepatitis B virus subgenotyping: history, effects of recombination, misclassifications, and corrections. Infect Genet Evol. 2013;16:355–361. - PubMed

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