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. 2015 Mar 10:2:7.
doi: 10.1186/s40779-015-0035-4. eCollection 2015.

Ebola virus disease: from epidemiology to prophylaxis

Wen Bin Liu #  1 , Zi Xiong Li #  1 , Yan Du  1 , Guang Wen Cao  1
Affiliations

Ebola virus disease: from epidemiology to prophylaxis

Wen Bin Liu et al. Mil Med Res. .

Abstract

The outbreak of Ebola virus disease (EVD) continues to spread through West Africa. Since the first report of EVD in March 2014, the number of cases has increased rapidly, with the fatality rate of >50%. The most prevalent Ebola virus belongs to the species of Zaire ebolavirus, with a fatality rate as high as 90%. Although there were cases introduced into other continents, Africa is the endemic area where fruit bats and apes are suspected to be Ebola virus carriers. The virus might be transmitted from the host animals to humans if humans consume raw or not fully cooked and contaminated meats. However, human-to-human transmission via close contact is the major route of current outbreaks. EVD can occur during any season and affect people of any race and age group. Direct contact with body fluids of EVD patients or living in contaminated environments greatly increases the risk of being infected. Transmission via aerosol less likely, but transmission via virus-containing droplets is possible in humans. Thus, health care providers are facing danger of getting Ebola virus infection. To date, vaccines, drugs and/or therapies to prevent Ebola virus infection or treat EVD are limited. Medical workers should follow the current standard prophylactic procedures. The military can orchestrate efficient care to mass EVD patients. Although it is necessary to speed up the pace of developing effective vaccine and therapeutics for the prevention and treatment of EVD, public health prevention and management should be important issue at present to control the spread of this disease cost-effectively.

Keywords: Ebola virus disease; Epidemiology; Outbreak; Prophylaxis; Virology.

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Figures

Figure 1
Figure 1
Case confirmation: Ebola virus disease.
See this image and copyright information in PMC

References

    1. Lemaitre C, Harper F, Pierron G, Heidmann T, Dewannieux M. The HERV-K Human Endogenous Retrovirus Envelope Protein Antagonizes Tetherin Antiviral Activity. J Virol. 2014;88:13626–37. doi: 10.1128/JVI.02234-14. - DOI - PMC - PubMed
    1. Pandey A, Atkins KE, Medlock J, Wenzel N, Townsend JP, Childs JE, et al. Strategies for containing Ebola in West Africa. Science. 2014;346:991–5. doi: 10.1126/science.1260612. - DOI - PMC - PubMed
    1. Team WHOER Ebola virus disease in West Africa–the first 9 months of the epidemic and forward projections. N Engl J Med. 2014;371:1481–95. doi: 10.1056/NEJMoa1411100. - DOI - PMC - PubMed
    1. Johnson KM, Lange JV, Webb PA, Murphy FA. Isolation and partial characterisation of a new virus causing acute haemorrhagic fever in Zaire. Lancet. 1977;1:569–71. doi: 10.1016/S0140-6736(77)92000-1. - DOI - PubMed
    1. Kuhn JH, Dodd LE, Wahl-Jensen V, Radoshitzky SR, Bavari S, Jahrling PB. Evaluation of perceived threat differences posed by filovirus variants. Biosecur Bioterror. 2011;9:361–71. doi: 10.1089/bsp.2011.0051. - DOI - PMC - PubMed

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