Treasure your exceptions: unusual domains in immune receptors reveal host virulence targets

Marc T Nishimura¹, Freddy Monteiro², Jeffery L Dangl³

Affiliations

¹ Department of Biology, University of North Carolina, Chapel Hill, NC 27599-3280, USA; Howard Hughes Medical Institute, University of North Carolina, Chapel Hill, NC 27599-3280, USA.
² Department of Biology, University of North Carolina, Chapel Hill, NC 27599-3280, USA.
³ Department of Biology, University of North Carolina, Chapel Hill, NC 27599-3280, USA; Howard Hughes Medical Institute, University of North Carolina, Chapel Hill, NC 27599-3280, USA; Curriculum in Genetics and Molecular Biology, University of North Carolina, Chapel Hill, NC 27599-3280, USA; Department of Microbiology and Immunology, University of North Carolina, Chapel Hill, NC 27599-3280, USA. Electronic address: dangl@email.unc.edu.

PMID: 26000473
DOI: 10.1016/j.cell.2015.05.017

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Treasure your exceptions: unusual domains in immune receptors reveal host virulence targets

Marc T Nishimura et al. Cell. 2015.

Free article

. 2015 May 21;161(5):957-960.

doi: 10.1016/j.cell.2015.05.017.

Authors

Marc T Nishimura¹, Freddy Monteiro², Jeffery L Dangl³

Affiliations

¹ Department of Biology, University of North Carolina, Chapel Hill, NC 27599-3280, USA; Howard Hughes Medical Institute, University of North Carolina, Chapel Hill, NC 27599-3280, USA.
² Department of Biology, University of North Carolina, Chapel Hill, NC 27599-3280, USA.
³ Department of Biology, University of North Carolina, Chapel Hill, NC 27599-3280, USA; Howard Hughes Medical Institute, University of North Carolina, Chapel Hill, NC 27599-3280, USA; Curriculum in Genetics and Molecular Biology, University of North Carolina, Chapel Hill, NC 27599-3280, USA; Department of Microbiology and Immunology, University of North Carolina, Chapel Hill, NC 27599-3280, USA. Electronic address: dangl@email.unc.edu.

PMID: 26000473
DOI: 10.1016/j.cell.2015.05.017

Abstract

A mechanistic understanding of how plant pathogens modulate their hosts is critical for rationally engineered disease resistance in agricultural systems. Two new studies show that genomically paired plant immune receptors have incorporated decoy domains that structurally mimic pathogen virulence targets to monitor attempted host immunosuppression.

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Treasure your exceptions: unusual domains in immune receptors reveal host virulence targets

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Treasure your exceptions: unusual domains in immune receptors reveal host virulence targets

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