Intraoperative OCT-Assisted DMEK: 14 Consecutive Cases

Abstract

Purpose: To describe the utility of a new intraoperative optical coherence tomographer (OCT) to evaluate endothelio-Descemet graft orientation during Descemet membrane endothelial keratoplasty (DMEK) procedures.

Methods: Prospective, observational, and single-center pilot case series including 14 eyes of 14 patients consecutively scheduled for DMEK surgery. After injecting the graft into the anterior chamber, the graft orientation was assessed with the help of anterior segment OCT. The surgical time and unfolding time were measured. The postoperative measurements included best-corrected visual acuity, central pachymetry, and specular microscopy at 1 month.

Results: Using the OCT images, it was possible to evaluate the graft orientation in all cases. The mean unfolding time was 6.1 ± 3.0 minutes, the mean best-corrected visual acuity was 0.3 ± 0.3 logarithm of the minimum angle of resolution, the mean decrease in central pachymetry was 213 ± 177 μm, and the mean central endothelial cell count was 1906 ± 319 cells per square millimeter.

Conclusions: Live intraoperative OCT is useful to visualize and assess graft orientation in DMEK surgery. It enables faster graft positioning with less graft manipulation in the presence of severe corneal edema.