Common variants at PRSS1-PRSS2 and CLDN2-MORC4 loci associate with chronic pancreatitis in Japan

Affiliations

Comment

Atsushi Masamune et al. Gut. 2015 Aug.

. 2015 Aug;64(8):1345-6.

doi: 10.1136/gutjnl-2015-309802. Epub 2015 May 22.

¹ Division of Gastroenterology, Tohoku University Graduate School of Medicine, Sendai, Japan.

No abstract available

Keywords: ALCOHOL; GENE MUTATION; PANCREATITIS; TRYPSIN; TRYPSINOGEN.

Comment in

PRSS1 copy number variants and promoter polymorphisms in pancreatitis: common pathogenetic mechanism, different genetic effects.
Masson E, Chen JM, Cooper DN, Férec C. Masson E, et al. Gut. 2018 Mar;67(3):592-593. doi: 10.1136/gutjnl-2017-314443. Epub 2017 Jun 10. Gut. 2018. PMID: 28601843 No abstract available.
Alcohol amplifies the association between common variants at PRSS1-PRSS2 locus and chronic pancreatitis in a dose-dependent manner.
Wang YC, Mao XT, Yu D, Mao SH, Li ZS, Zou WB, Liao Z. Wang YC, et al. Gut. 2022 Nov;71(11):2369-2371. doi: 10.1136/gutjnl-2021-326670. Epub 2022 Jan 7. Gut. 2022. PMID: 34996825 No abstract available.

Polymorphisms at PRSS1-PRSS2 and CLDN2-MORC4 loci associate with alcoholic and non-alcoholic chronic pancreatitis in a European replication study.
Derikx MH, Kovacs P, Scholz M, Masson E, Chen JM, Ruffert C, Lichtner P, Te Morsche RH, Cavestro GM, Férec C, Drenth JP, Witt H, Rosendahl J; PanEuropean Working group on Alcoholic Chronic Pancreatitis Members and Collaborators. Derikx MH, et al. Gut. 2015 Sep;64(9):1426-33. doi: 10.1136/gutjnl-2014-307453. Epub 2014 Sep 24. Gut. 2015. PMID: 25253127