The biology of aging and lymphoma: a complex interplay
- PMID: 26003736
- DOI: 10.1007/s11912-015-0457-x
The biology of aging and lymphoma: a complex interplay
Abstract
The probability to develop non-Hodgkin lymphoma grows with age. The biological links between aging and lymphoma are not well described in the literature, and different hypothesis may be raised to explain this complex relationship. First, the impact of chronological age favoring the accumulation of genetic alterations can contribute to the multisteps proces of lymphomagenesis. Then, the age-related defects in cancer protection and the age-related clonal restriction in hematopoietic stem cell may also promote lymphoma development. Finally, the senescent and immunosenescence phenotype might represent a key process explaining this link. In this review, we will explore the current available clinical data and their ability to apply to age-related regulation pathways.
Similar articles
-
Non-Hodgkin's lymphoma: the old and the new.Clin Lymphoma Myeloma Leuk. 2011 Jun;11 Suppl 1:S87-90. doi: 10.1016/j.clml.2011.03.029. Epub 2011 Apr 28. Clin Lymphoma Myeloma Leuk. 2011. PMID: 22035756 Review.
-
Hepatitis C virus - associated B cell non-Hodgkin's lymphoma.World J Gastroenterol. 2016 Jul 21;22(27):6214-23. doi: 10.3748/wjg.v22.i27.6214. World J Gastroenterol. 2016. PMID: 27468211 Free PMC article. Review.
-
Nodular lymphoid hyperplasia of the small bowel associated with primary jejunal malignant lymphoma. Evidence favoring a cytogenetic relationship.Gastroenterology. 1980 Jun;78(6):1587-92. Gastroenterology. 1980. PMID: 6989706
-
Histiocytic lymphoma of B cell origin.Arch Intern Med. 1977 Jun;137(6):800-3. Arch Intern Med. 1977. PMID: 326214
-
CD20-negative relapse after (131)I-anti-CD20 therapy.J Clin Oncol. 1999 Nov;17(11):3692-3. doi: 10.1200/JCO.1999.17.11.3692. J Clin Oncol. 1999. PMID: 10550173 No abstract available.
Cited by
-
Current Treatment Options and the Role of Functional Status Assessment in Classical Hodgkin Lymphoma in Older Adults: A Review.Cancers (Basel). 2023 Feb 28;15(5):1515. doi: 10.3390/cancers15051515. Cancers (Basel). 2023. PMID: 36900306 Free PMC article. Review.
-
First-line Treatment With Bendamustine and Rituximab for Old and Frail Patients With Aggressive Lymphoma: Results of the B-R-ENDA Trial.Hemasphere. 2022 Dec 1;6(12):e808. doi: 10.1097/HS9.0000000000000808. eCollection 2022 Dec. Hemasphere. 2022. PMID: 36479544 Free PMC article.
-
Primary Effusion Lymphoma: A Timely Review on the Association with HIV, HHV8, and EBV.Diagnostics (Basel). 2022 Mar 15;12(3):713. doi: 10.3390/diagnostics12030713. Diagnostics (Basel). 2022. PMID: 35328266 Free PMC article. Review.
-
Differentially Expressed Genes and Molecular Susceptibility to Human Age-Related Diseases.Int J Mol Sci. 2023 Feb 16;24(4):3996. doi: 10.3390/ijms24043996. Int J Mol Sci. 2023. PMID: 36835409 Free PMC article.
-
Prognostic Analysis of Patients with Primary Extranodal Lymphoma: A Retrospective Study.Cancer Manag Res. 2021 Mar 2;13:2171-2180. doi: 10.2147/CMAR.S299745. eCollection 2021. Cancer Manag Res. 2021. PMID: 33688260 Free PMC article.
References
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Medical