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Comment
. 2015 Jul 7;22(1):54-6.
doi: 10.1016/j.cmet.2015.05.009. Epub 2015 May 20.

GDF11 and the Mythical Fountain of Youth

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GDF11 and the Mythical Fountain of Youth

Caroline E Brun et al. Cell Metab. .
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Abstract

Identifying candidates that rejuvenate aged muscle stem cells is an important strategy toward developing therapies to treat age-related diseases. In this issue, Egerman et al. (2015) re-investigate the activity of GDF11 in myogenesis, recently suggested as an anti-aging agent, and instead find a potent inhibitory effect on skeletal muscle regeneration.

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  • GDF11 Increases with Age and Inhibits Skeletal Muscle Regeneration.
    Egerman MA, Cadena SM, Gilbert JA, Meyer A, Nelson HN, Swalley SE, Mallozzi C, Jacobi C, Jennings LL, Clay I, Laurent G, Ma S, Brachat S, Lach-Trifilieff E, Shavlakadze T, Trendelenburg AU, Brack AS, Glass DJ. Egerman MA, et al. Cell Metab. 2015 Jul 7;22(1):164-74. doi: 10.1016/j.cmet.2015.05.010. Epub 2015 May 19. Cell Metab. 2015. PMID: 26001423 Free PMC article.

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