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Review
. 2015 Jun;35(2):363-91.
doi: 10.1016/j.cll.2015.02.012.

Rotavirus

Mathew D Esona  1 , Rashi Gautam  2
Affiliations
Review

Rotavirus

Mathew D Esona et al. Clin Lab Med. 2015 Jun.

Abstract

Group A rotavirus (RVA) is the major cause of acute gastroenteritis (AGE) in young children worldwide. Introduction of two live, attenuated rotavirus vaccines, Rotarix® and RotaTeq®, has dramatically reduced RVA-associated AGE and mortality. High-throughput, sensitive and specific techniques are required to rapidly diagnose and characterize rotavirus strains in stool samples for proper patient treatment and to monitor circulating vaccine and wild-type rotavirus strains. New molecular assays are rapidly developed that are more sensitive and specific than the conventional assays for detection, genotyping and full genome characterization of circulating rotavirus wild-type and vaccine (Rotarix® and RotaTeq®) strains causing AGE.

Keywords: Acute gastroenteritis; Multiplex assays; Next-generation sequencing; RotaTeq®; Rotarix®; Rotavirus; Rotavirus vaccines; qRT-PCR.

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