Review
doi: 10.1016/j.molimm.2015.05.002.
Epub 2015 May 23.
Are ERAD components involved in cross-presentation?
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- PMID: 26005101
- DOI: 10.1016/j.molimm.2015.05.002
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Review
Are ERAD components involved in cross-presentation?
Mol Immunol.
2015 Dec.
Abstract
A long unanswered question in the antigen presentation field is how exogenous antigens cross-presented by Major Histocompatibility Complex class I (MHC-I) molecules to CD8(+) T cells are translocated into the cytosol. Here we discuss the known mechanisms involved in this process with a focus on the hypothesized role of the machinery that functions in endoplasmic reticulum-associated degradation (ERAD). Other potential mechanisms of antigen entry to the cytosol are also discussed.
Keywords: Antigen processing; Cross-presentation; Dendritic cells; ERAD; MHC.
Copyright © 2015 Elsevier Ltd. All rights reserved.
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