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. 2015 Apr;27(2):99-103.
doi: 10.5455/msm.2015.27.99-103. Epub 2015 Apr 5.

Elevated Serum Leptin Level Is Associated with Body Mass Index But Not with Serum C-reactive Protein and Erythrocyte Sedimentation Rate Values in Hemodialysis Patients

Amela Dervisevic  1 , Anela Subo  2 , Nesina Avdagic  1 , Asija Zaciragic  1 , Nermina Babic  1 , Almir Fajkic  3 , Orhan Lepara  1 , Almira Hadzovic-Dzuvo  1
Affiliations

Elevated Serum Leptin Level Is Associated with Body Mass Index But Not with Serum C-reactive Protein and Erythrocyte Sedimentation Rate Values in Hemodialysis Patients

Amela Dervisevic et al. Mater Sociomed. 2015 Apr.

Abstract

Objectives: Aim of the present study was to investigate serum concentration of leptin and its association with values of body mass index (BMI), C-reactive protein (CRP), and erythrocyte sedimentation rate (ESR) in hemodialysis (HD) patients.

Methods: This cross-sectional study included 60 HD patients (34 male, 26 female) and 30 age- and sex-matched (4 males, 26 females) apparently healthy subjects. Serum leptin concentration was determined by an enzyme-linked immunosorbent assay (ELISA). Serum CRP concentration was measured by means of particle-enhanced immunonephelometry. ESR value was determined by Western Green method. BMI was calculated as weight (kg) divided by height squared (m(2)).

Results: Results have shown that median serum leptin concentration (30.65 ng/mL; 12.48-86.40 ng/mL) was statistically significantly higher in HD patients compared to median serum leptin concentration (15.75 ng/mL; 9.15-30.65 ng/mL) in the control group of healthy subjects (p<0.05). Likewise, median serum CRP concentration (5.5 mg/L; 1.93-8.9 mg/L) and median ESR value (57.5 mm/h; 40.5-77.0 mm/h) were significantly higher in HD patients compared to median serum CRP concentration (0.8 mg/L; 0.38-1.43 mg/L) (p<0.001) and median ESR value (10.0 mm/h; 6.5-14.0 mm/h) (p<0.001) determined in the control group. Statistically significant positive correlation was found between BMI values and serum leptin concentration in HD patients (rho=0.434; p<0.001). Positive, although not significant, correlation was observed between serum CRP and leptin levels in HD patients (rho=0.171; p>0.05). Negative correlation between ESR values and serum leptin concentrations in HD patients was determined but it was not statistically significant (rho= -0.029; p>0.05).

Conclusions: Increased serum concentration of leptin as pro-inflammatory cytokine as well as elevated serum values of CRP and ESR indicate presence of systemic micro inflammation in HD patients. Results of the present study point to possible use of serum leptin concentration as an indicator of nutritional status in HD patients based on observed significant positive correlation between serum leptin concentrations and BMI values. However, absence of significant association between serum leptin and CRP levels as well as between serum leptin concentrations and ESR values in HD patients requires further investigation and clarification.

Keywords: Body Mass Index (BMI); C-reactive protein (CRP); Erythrocyte sedimentation rate (ESR); Hemodialysis (HD) patients; Leptin.

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Conflict of interest statement

CONFLICT OF INTEREST: NONE DECLARED.

Figures

Figure 1
Figure 1
Serum leptin concentration in the control group (CG) and in the group of hemodialysis (HD) patients
Figure 2
Figure 2
Serum C-reactive protein (CRP) concentration in the control group (CG) and in the group of hemodialysis (HD) patients
Figure 3
Figure 3
Serum erythrocyte sedimentation rate (ESR) value in the control group (CG) and in the group of hemodialysis (HD) patients
Figure 4
Figure 4
Correlation between body mass index (BMI) values and serum leptin concentrations in hemodialysis (HD) patients
See this image and copyright information in PMC

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