Management of gastrointestinal involvement in scleroderma
- PMID: 26005632
- PMCID: PMC4437639
- DOI: 10.1007/s40674-014-0005-0
Management of gastrointestinal involvement in scleroderma
Abstract
Gastrointestinal tract (GIT) commonly affects patients with systemic sclerosis (SSc). The GI involvement is quite heterogeneous varying from asymptomatic disease to significant dysmotility causing complications like malabsorption, weight loss and severe malnutrition. This review focuses on the management of GI involvement in SSc and has been categorized based on the segment of GIT involved. A brief discussion on the role of patient reported outcome measures in SSc-GI involvement has also been incorporated.
Keywords: Gastrointestinal tract; bacterial overgrowth; constipation; diarrhea; dysphagia; gastric antral vascular ectasia; gastroesophageal reflux; gastroparesis; intestinal dysmotility; nutrition; scleroderma; systemic sclerosis.
Similar articles
-
[Gastrointestinal features in systemic sclerosis].Rev Med Suisse. 2014 Apr 16;10(426):860-3. Rev Med Suisse. 2014. PMID: 24834644 French.
-
Severe gastrointestinal involvement in systemic sclerosis: report of five cases and review of the literature.Semin Arthritis Rheum. 2005 Feb;34(4):689-702. doi: 10.1016/j.semarthrit.2004.08.009. Semin Arthritis Rheum. 2005. PMID: 15692963 Review.
-
Responsiveness of the University of California Los Angeles Scleroderma Clinical Trial Consortium gastrointestinal tract 2.0 (UCLA-SCTC-GIT 2.0)to change in scleroderma patients.J Scleroderma Relat Disord. 2021 Oct;6(3):236-241. doi: 10.1177/2397198321992197. Epub 2021 Feb 22. J Scleroderma Relat Disord. 2021. PMID: 35387210 Free PMC article.
-
A Phenome-Wide Association Study of Drugs and Comorbidities Associated With Gastrointestinal Dysfunction in Systemic Sclerosis.J Rheumatol. 2023 Jul;50(7):907-915. doi: 10.3899/jrheum.220990. Epub 2023 Feb 15. J Rheumatol. 2023. PMID: 36792109
-
Nutrition in systemic sclerosis.Reumatol Clin. 2012 May-Jun;8(3):135-40. doi: 10.1016/j.reuma.2011.09.006. Epub 2011 Dec 24. Reumatol Clin. 2012. PMID: 22197834 Review.
Cited by
-
Use of vonoprazan, a novel potassium-competitive acid blocker, for the treatment of proton pump inhibitor-refractory reflux esophagitis in patients with systemic sclerosis.J Scleroderma Relat Disord. 2022 Feb;7(1):57-61. doi: 10.1177/23971983211021747. Epub 2021 Jun 7. J Scleroderma Relat Disord. 2022. PMID: 35386943 Free PMC article.
-
Evidence for targeting autonomic dysfunction in systemic sclerosis: A scoping review.J Scleroderma Relat Disord. 2025 Jan 8:23971983241308050. doi: 10.1177/23971983241308050. Online ahead of print. J Scleroderma Relat Disord. 2025. PMID: 39790996 Free PMC article. Review.
-
Systemic sclerosis.Lancet. 2023 Jan 28;401(10373):304-318. doi: 10.1016/S0140-6736(22)01692-0. Epub 2022 Nov 25. Lancet. 2023. PMID: 36442487 Free PMC article. Review.
-
An Obstructing Fecal Bezoar in a Patient with Scleroderma with Successful Colonoscopic Disimpaction.ACG Case Rep J. 2019 Apr 11;6(4):e00059. doi: 10.14309/crj.0000000000000059. eCollection 2019 Apr. ACG Case Rep J. 2019. PMID: 31616740 Free PMC article.
-
Intestinal hypomotility in systemic sclerosis: a histological study into the sequence of events.Clin Rheumatol. 2021 Mar;40(3):981-990. doi: 10.1007/s10067-020-05325-8. Epub 2020 Aug 18. Clin Rheumatol. 2021. PMID: 32812181 Free PMC article.
References
-
- Al-Dhaher FF, Pope JE, Ouimet JM. Determinants of morbidity and mortality of systemic sclerosis in Canada. Seminars in arthritis and rheumatism. 2010;39(4):269–77. - PubMed
-
- Bodukam V, Hays RD, Maranian P, Furst DE, Seibold JR, Impens A, et al. Association of gastrointestinal involvement and depressive symptoms in patients with systemic sclerosis. Rheumatology. 2011;50(2):330–4. [This reference highlights the burden of GI involvement in patients with SSc.] - PMC - PubMed
-
- Omair MA, Lee P. Effect of gastrointestinal manifestations on quality of life in 87 consecutive patients with systemic sclerosis. The Journal of rheumatology. 2012;39(5):992–6. - PubMed
-
- Butt S, Emmanuel A. Systemic sclerosis and the gut. Expert review of gastroenterology & hepatology. 2013;7(4):331–9. - PubMed
-
- Jaovisidha K, Csuka ME, Almagro UA, Soergel KH. Severe gastrointestinal involvement in systemic sclerosis: report of five cases and review of the literature. Seminars in arthritis and rheumatism. 2005;34(4):689–702. - PubMed
Grants and funding
LinkOut - more resources
Full Text Sources
Other Literature Sources