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. 2015 Oct;69(4):595-600.
doi: 10.1007/s11418-015-0920-x. Epub 2015 May 26.

Manadodioxans A-E: polyketide endoperoxides from the marine sponge Plakortis bergquistae

Masaki Gushiken  1 , Ippei Kagiyama, Hikaru Kato, Toshiyuki Kuwana, Fitje Losung, Remy E P Mangindaan, Nicole J de Voogd, Sachiko Tsukamoto
Affiliations

Manadodioxans A-E: polyketide endoperoxides from the marine sponge Plakortis bergquistae

Masaki Gushiken et al. J Nat Med. 2015 Oct.

Abstract

Five new polyketide endoperoxides, manadodioxans A-E, were isolated from the marine sponge Plakortis bergquistae. Manadodioxan E showed antimicrobial activity against Escherichia coli at 10 μg/disk, while its oxo congener, manadodioxan D, was inactive.

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