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Review
. 2015 May 8;7(5):1556-615.
doi: 10.3390/toxins7051556.

Ribosome-inactivating and related proteins

Joachim Schrot  1 , Alexander Weng  2 , Matthias F Melzig  3
Affiliations
Review

Ribosome-inactivating and related proteins

Joachim Schrot et al. Toxins (Basel). .

Abstract

Ribosome-inactivating proteins (RIPs) are toxins that act as N-glycosidases (EC 3.2.2.22). They are mainly produced by plants and classified as type 1 RIPs and type 2 RIPs. There are also RIPs and RIP related proteins that cannot be grouped into the classical type 1 and type 2 RIPs because of their different sizes, structures or functions. In addition, there is still not a uniform nomenclature or classification existing for RIPs. In this review, we give the current status of all known plant RIPs and we make a suggestion about how to unify those RIPs and RIP related proteins that cannot be classified as type 1 or type 2 RIPs.

Keywords: N-glycosidase; RIP 1; RIP 2; RIPs; classification of RIPs; nomenclature of RIPs; ribosome-inactivating proteins; type 1 RIP; type 2 RIP.

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