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Comment
. 2015 Jun;145(6):481-3.
doi: 10.1085/jgp.201511411.

Orchestrating Ca2+ influx through Ca(V)1.2 and Ca(V)3.x channels in human cerebral arteries

Daniel M Collier  1 , David C Hill-Eubanks  1 , Mark T Nelson  2
Affiliations
Comment

Orchestrating Ca2+ influx through Ca(V)1.2 and Ca(V)3.x channels in human cerebral arteries

Daniel M Collier et al. J Gen Physiol. 2015 Jun.
No abstract available

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Figures

Figure 1.
Figure 1.
Model of the contribution of CaV channels to smooth muscle tone. CaV1.2 (dark blue) and CaV3.3 (purple) promote smooth muscle contraction by allowing Ca2+ entry. The relative contribution of each depends on intraluminal pressure (or membrane potential). CaV1.2 is the major contributor between −50 and −35 mV (higher pressure, >40 mm Hg) whereas CaV3.3 is the major contributor between −60 and −50 mV (lower pressure, 20–40 mm Hg). CaV3.2 (light blue) opposes contraction through activation of Ca2+ sparks/RyRs through BK channel–dependent membrane hyperpolarization. Model is based on the data of Harraz et al. (2015).
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