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Case Reports
. 1989 Sep;53(9):1077-80.
doi: 10.1253/jcj.53.1077.

A digoxin-like immunoreactive substance and atrioventricular block induced by a Chinese medicine "kyushin"

C S Lin  1 , M C Lin, K S Chen, C C Ho, S R Tsai, C S Ho, W H Shieh
Affiliations
Case Reports

A digoxin-like immunoreactive substance and atrioventricular block induced by a Chinese medicine "kyushin"

C S Lin et al. Jpn Circ J. 1989 Sep.

Abstract

The attempted suicide by 2 women with a kyushin overdose is reported. Kyushin caused them to produce a significant elevation of a serum digoxin-like immunoreactive substance (2.35 and 1.84 ng/ml) and symptoms of nausea, vomiting and general malaise. Their blood biochemistry and electrolytes were normal. In one patient, an electrocardiogram revealed a second degree Wenckebach atrioventricular block and T-wave change. Toad venom, a kyushin ingredient, is possibly responsible for the development of these clinical features and electrocardiographic changes.

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