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. 2015 May 26;10(5):e0127666.
doi: 10.1371/journal.pone.0127666. eCollection 2015.

Association between Dietary Magnesium Intake and Radiographic Knee Osteoarthritis

Chao Zeng  1 , Hui Li  1 , Jie Wei  2 , Tuo Yang  1 , Zhen-han Deng  1 , Ye Yang  1 , Yi Zhang  1 , Tu-bao Yang  2 , Guang-hua Lei  1
Affiliations

Association between Dietary Magnesium Intake and Radiographic Knee Osteoarthritis

Chao Zeng et al. PLoS One. .

Abstract

Objective: To examine the cross-sectional associations between dietary magnesium (Mg) intake and radiographic knee osteoarthritis (OA), joint space narrowing (JSN), and osteophytes (OST) respectively.

Methods: A total of 1626 subjects were included in the study. Dietary intake was assessed using a validated semi-quantitative food frequency questionnaire. Radiographic knee OA was defined as Kellgren-Lawrence (K-L) Grade 2 in at least one leg. JSN and OST were assessed individually according to the Osteoarthritis Research Society International (OARSI) atlas. A multivariable logistic analysis model was applied to test the various associations after adjusting for potentially confounding factors.

Results: The relative odds of radiographic knee OA were decreased by 0.53 times in the third quintile of Mg intake [odds ratio (OR) 0.53, 95% confidence interval (CI) 0.28-1.01], 0.40 times in the fourth quintile (OR 0.40, 95% CI 0.17-0.94) and 0.34 times in the fifth quintile (OR 0.34, 95% CI 0.11-1.00) compared with those in the lowest quintile, while P for trend was 0.111. The relative odds of JSN were decreased by 0.49 times in the third quintile of Mg intake (OR 0.49, 95% CI 0.28-0.88) and 0.37 times in the fifth quintile (OR 0.37, 95% CI 0.14-0.98) compared with those in the lowest quintile, while P for trend was 0.088. There was no significant relationship between dietary Mg intake and the presence of OST.

Conclusions: The findings of this cross-sectional study indicate that Mg intake is inversely associated with radiographic knee OA and JSN. It supports potential role of Mg in the prevention of knee OA.

Level of evidence: LevelIII, cross-sectional study.

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Conflict of interest statement

Competing Interests: The authors have declared that no competing interests exist.

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