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Randomized Controlled Trial
. 2015 May 26;10(5):e0127956.
doi: 10.1371/journal.pone.0127956. eCollection 2015.

The diagnostic accuracy of urine lipoarabinomannan test for tuberculosis screening in a South African correctional facility

Yasmeen Hanifa  1 , Lilanganee Telisinghe  2 , Katherine L Fielding  3 , Justin L Malden  2 , Gavin J Churchyard  4 , Alison D Grant  3 , Salome Charalambous  5
Affiliations
Randomized Controlled Trial

The diagnostic accuracy of urine lipoarabinomannan test for tuberculosis screening in a South African correctional facility

Yasmeen Hanifa et al. PLoS One. .

Abstract

Background: We evaluated the diagnostic accuracy of the urine lipoarabinomannan (LAM) antigen detection assay (Clearview TB-ELISA) to screen for tuberculosis in a South African correctional facility.

Methods: Between September 2009 and October 2010, male offenders were screened for tuberculosis (symptoms, chest radiograph, two spot sputum specimens for microscopy and culture), and urine tested for LAM. Sensitivity, specificity and predictive values of LAM were calculated using definite and probable tuberculosis combined as our gold standard.

Findings: 33/871 (3.8%) participants (26% HIV-positive) had tuberculosis. Amongst HIV-positive vs. HIV-negative offenders the sensitivity and specificity of LAM was 7.1% vs. 0% and 98.5% vs. 99.8% respectively.

Conclusion: Urine LAM ELISA has inadequate sensitivity for TB screening in this population.

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Conflict of interest statement

Competing Interests: The authors have declared that no competing interests exist.

Figures

Fig 1
Fig 1. Participant flow chart.
LAM = lipoarabinomannan; TB = tuberculosis; S +ve = sputum smear-positive for acid-fast bacilli; S –ve = sputum smear-negative for acid-fast bacilli; C +ve = sputum culture-positive for M. tuberculosis; C –ve = sputum culture-negative for M. tuberculosis; CXR +ve = classical radiographic features of TB.
See this image and copyright information in PMC

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