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. 2015 May 27:5:10593.
doi: 10.1038/srep10593.

Comparison between 200 mg QD and 100 mg BID oral celecoxib in the treatment of knee or hip osteoarthritis

Chao Zeng  1 , Jie Wei  2 , Hui Li  1 , Tuo Yang  1 , Shu-guang Gao  1 , Yu-sheng Li  1 , Yi-Lin Xiong  1 , Wen-feng Xiao  1 , Wei Luo  1 , Tu-bao Yang  2 , Guang-hua Lei  1
Affiliations

Comparison between 200 mg QD and 100 mg BID oral celecoxib in the treatment of knee or hip osteoarthritis

Chao Zeng et al. Sci Rep. .

Abstract

This network meta-analysis aimed to investigate the effectiveness and safety of 100 mg BID and 200 mg QD oral celecoxib in the treatment of OA of the knee or hip. PubMed, Embase and Cochrane Library were searched through from inception to August 2014. Bayesian network meta-analysis was used to combine direct and indirect evidences on treatment effectiveness and safety. A total of 24 RCTs covering 11696 patients were included. For the comparison in between the two dosage regimens, 100 mg BID oral celecoxib exhibited a greater probability to be the preferred one either in terms of pain intensity or function at the last follow-up time point. For total gastrointestinal (GI) adverse effects (AEs), both of the two dosage regimens demonstrated a higher incidence compared to the placebo group. Further analyses of GI AEs revealed that only 200 mg QD was associated with a significantly higher risk of abdominal pain when compared with placebo. Furthermore, 100 mg BID showed a significantly lower incidence of skin AEs when compared with 200 mg QD and placebo. Maybe 100 mg BID should be considered as the preferred dosage regimen in the treatment of knee or hip OA.

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Figures

Figure 1
Figure 1
Summary of studies identification and selection.
Figure 2
Figure 2
Structure of network formed by interventions and their direct comparisons. The lines between treatment nodes indicate the direct comparisons made within randomized trials.
Figure 3
Figure 3
Network meta-analysis estimates-standard mean difference (SMD) of pain relief and function improvement for three compared groups.
Figure 4
Figure 4
Rankings for three treatments. Graph displays distribution of probabilities for each treatment. X-axis represents the possible rank of each treatment (from the best rank to worse according to the outcomes), Y-axis represents the cumulative probability for each treatment to be the best option, among the best two options, among the best three options, and so on.
Figure 5
Figure 5
Network meta-analysis estimates-odds ratios (OR) of eight kinds of AEs for three compared groups.
Figure 6
Figure 6
Network meta-analysis estimates-odds ratios (OR) of six kinds of GI AEs for three compared groups.
See this image and copyright information in PMC

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