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. 2015 May 27:5:10645.
doi: 10.1038/srep10645.

The prognostic factors and multiple biomarkers in young patients with colorectal cancer

Mo-Jin Wang  1 , Jie Ping  2 , Yuan Li  3 , Gunnar Adell  2 , Gunnar Arbman  4 , Bjorn Nodin  5 , Wen-Jian Meng  1 , Hong Zhang  6 , Yong-Yang Yu  7 , Cun Wang  7 , Lie Yang  7 , Zong-Guang Zhou  7 , Xiao-Feng Sun  1
Affiliations

The prognostic factors and multiple biomarkers in young patients with colorectal cancer

Mo-Jin Wang et al. Sci Rep. .

Abstract

The incidence of colorectal cancer (CRC) in young patients (≤ 50 years of age) appears to be increasing. However, their clinicopathological characteristics and survival are controversial. Likewise, the biomarkers are unclear. We used the West China (2008-2013, China), Surveillance, Epidemiology, and End Results program (1973-2011, United States) and Linköping Cancer (1972-2009, Sweden) databases to analyse clinicopathological characteristics, survival and multiple biomarkers of young CRC patients. A total of 509,934 CRC patients were included from the three databases. The young CRC patients tended to have more distal location tumours, fewer tumour numbers, later stage, more mucinous carcinoma and poorer differentiation. The cancer-specific survival (CSS) of young patients was significantly better. The PRL (HR = 12.341, 95% CI = 1.615-94.276, P = 0.010), RBM3 (HR = 0.093, 95% CI = 0.012-0.712, P = 0.018), Wrap53 (HR = 1.952, 95% CI = 0.452-6.342, P = 0.031), p53 (HR = 5.549, 95% CI = 1.176-26.178, P = 0.045) and DNA status (HR = 17.602, 95% CI = 2.551-121.448, P = 0.001) were associated with CSS of the young patients. In conclusion, this study suggests that young CRC patients present advanced tumours and more malignant pathological features, while they have a better prognosis. The PRL, RBM3, Wrap53, p53 and DNA status are potential prognostic biomarkers for the young CRC patients.

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Figures

Figure 1
Figure 1
The cancer-specific survival of young and elderly CRC patients in (a) SEER, P < 0.001 and (b) LC, P = 0.102.
Figure 2
Figure 2
The disease-free survival (DFS) of young and elderly CRC patients in LC. The DFS was not significantly different between two age groups, P = 0.690.
See this image and copyright information in PMC

References

    1. Garcia M. et al. Global Cancer Facts & Figures 2007. Atlanta, GA: American Cancer Society (2007), www.cancer.org/acs/groups/content/@nho/documents/document/globalfactsand.... [accessed March 1, 2015].
    1. Edwards B. K. et al. Annual report to the nation on the status of cancer, 1975-2006, featuring colorectal cancer trends and impact of interventions (risk factors, screening, and treatment) to reduce future rates. Cancer 116, 544–573 (2010). - PMC - PubMed
    1. Siegel R., Naishadham D. & Jemal A. Cancer statistics, 2013. CA Cancer J Clin 63, 11–30 (2013). - PubMed
    1. Allemani C. et al. Global surveillance of cancer survival 1995-2009: analysis of individual data for 25 676 887 patients from 279 population-based registries in 67 countries (CONCORD-2). Lancet 385, 977–1010 (2015). - PMC - PubMed
    1. Sung J. J., Lau J. Y., Goh K. L., Leung W. K. & Asia Pacific Working Group on Colorectal, C. Increasing incidence of colorectal cancer in Asia: implications for screening. Lancet Oncol 6, 871–876 (2005). - PubMed

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