MERFISHing for spatial context

Alex K Shalek¹, Rahul Satija²

Affiliations

¹ Institute for Medical Engineering & Science & Department of Chemistry, MIT, Cambridge, MA, USA; Ragon Institute of MGH, MIT, & Harvard, Cambridge, MA, USA; Broad Institute of MIT & Harvard, Cambridge, MA, USA.
² New York Genome Center, New York, NY, USA; New York University, Center for Genomics and Systems Biology, New York, NY, USA. Electronic address: rahuls@broadinstitute.org.

PMID: 26013647
DOI: 10.1016/j.it.2015.05.002

Comment

MERFISHing for spatial context

Alex K Shalek et al. Trends Immunol. 2015 Jul.

. 2015 Jul;36(7):390-1.

doi: 10.1016/j.it.2015.05.002. Epub 2015 May 23.

Authors

Alex K Shalek¹, Rahul Satija²

Affiliations

¹ Institute for Medical Engineering & Science & Department of Chemistry, MIT, Cambridge, MA, USA; Ragon Institute of MGH, MIT, & Harvard, Cambridge, MA, USA; Broad Institute of MIT & Harvard, Cambridge, MA, USA.
² New York Genome Center, New York, NY, USA; New York University, Center for Genomics and Systems Biology, New York, NY, USA. Electronic address: rahuls@broadinstitute.org.

PMID: 26013647
DOI: 10.1016/j.it.2015.05.002

Abstract

A new paper in Science by Zhuang and colleagues introduces multiplexed error-robust FISH (MERFISH). MERFISH extends single-molecule imaging techniques to profile the copy number and localization patterns of thousands of genes, representing a major advance for spatial transcriptomics, with exciting potential applications in immunology.

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RNA imaging. Spatially resolved, highly multiplexed RNA profiling in single cells.
Chen KH, Boettiger AN, Moffitt JR, Wang S, Zhuang X. Chen KH, et al. Science. 2015 Apr 24;348(6233):aaa6090. doi: 10.1126/science.aaa6090. Epub 2015 Apr 9. Science. 2015. PMID: 25858977 Free PMC article.

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MERFISHing for spatial context

Affiliations

MERFISHing for spatial context

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