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. 2015 Oct;22(20):15579-86.
doi: 10.1007/s11356-015-4712-3. Epub 2015 May 28.

Effects of chitin and its derivatives on human cancer cells lines

M Bouhenna  1 , R Salah  1 , R Bakour  2 , N Drouiche  3   4 , N Abdi  1 , H Grib  1 , H Lounici  1   5 , N Mameri  1
Affiliations

Effects of chitin and its derivatives on human cancer cells lines

M Bouhenna et al. Environ Sci Pollut Res Int. 2015 Oct.

Abstract

The present study is focused on the effect of chitin derivatives against human cancer cell lines RD and Hep2. As an outcome from this research, chitin was cytotoxic at IC50 = 400 μg/ml and 200 μg/ml against Hep2 cells and RD cells lines, respectively. Irradiated chitin had an IC50 value of 450 μg/ml for Hep2 and an IC50 of 200 μg/ml for RD. The lowest IC50 is attributed to chitosan, 300 μg/ml in Hep2 and 190 μg/ml in RD.

Keywords: Biopolymers; Chitin; Chitosan; Cytotoxicity; Enzymatic hydrolysis.

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