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Review
. 2015 Aug:33:1-10.
doi: 10.1016/j.pupt.2015.05.006. Epub 2015 May 23.

Therapeutic novelties of inhaled corticosteroids and bronchodilators in asthma

Fabio L M Ricciardolo  1 , Francesco Blasi  2 , Stefano Centanni  3 , Paola Rogliani  4
Affiliations
Review

Therapeutic novelties of inhaled corticosteroids and bronchodilators in asthma

Fabio L M Ricciardolo et al. Pulm Pharmacol Ther. 2015 Aug.

Abstract

Orally inhaled agents are a key therapeutic class for treatment of asthma. Inhaled corticosteroids (ICS) are the most effective anti-inflammatory treatment for asthma thus representing the first-line therapy and bronchodilators complement the effects of ICSs. A significant body of evidence indicates that addition of a β2-agonist to ICS therapy is more effective than increasing the dose of ICS monotherapy. In this paper, pharmacological features of available ICSs and bronchodilators will be reviewed with a focus on fluticasone propionate/formoterol fumarate combination which represents the one of the most powerful ICS acting together with the most rapid active LABA.

Keywords: Asthma; Bronchodilator; Inhaled corticosteroid; Long-acting β2 agonist.

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