Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2015 Mar-Apr;19(2):164-8.
doi: 10.4103/0972-124X.152105.

Comparison of the number of gingival blood vessels between type 2 diabetes mellitus and chronic periodontitis patients: An immunohistological study

Gautami Subhadra Penmetsa  1 , Satyanarayana Baddam  1 , Ravikanth Manyam  2 , Chinni Doraswamy Dwarakanath  1
Affiliations

Comparison of the number of gingival blood vessels between type 2 diabetes mellitus and chronic periodontitis patients: An immunohistological study

Gautami Subhadra Penmetsa et al. J Indian Soc Periodontol. 2015 Mar-Apr.

Abstract

Background: The relationship between diabetes and periodontitis has been studied for more than 50 years and is generally agreed that the periodontal disease is more prevalent in diabetic patients compared to nondiabetics. Vascular changes like increased thickness of basement membrane in small vessels has been reported in diabetic patients, but the quantity of blood vessels in gingiva of diabetic patients has not been discussed much. The aim of this study was to compare the number of blood vessels in gingiva between chronic periodontitis (CP) patients, CP with diabetes (type 2), and normal healthy gingiva.

Materials and methods: The study included 75 patients, divided into three groups of 25 patients each-Group I with healthy periodontium (HP), Group II with CP, and Group III with CP with diabetes mellitus (CPDM). Gingival biopsies were obtained from the subjects undergoing crown lengthening procedure for Group I, and in patients with CP and in CPDM biopsies were collected from teeth undergoing extraction. Sections were prepared for immune histochemical staining with CD34.

Results: Difference was observed in the average number of blood vessels when compared between HP, CP, and CPDM groups. Statistical significant difference was observed when the HP and CP groups and HP and CPDM groups were compared.

Conclusion: The results of the study indicated that the number of blood vessels in gingival connective tissue is significantly higher in CP and CPDM patients.

Keywords: CD34; chronic periodontitis with diabetes; mean vessel number; periodontitis; type 2 diabetes.

PubMed Disclaimer

Conflict of interest statement

Conflict of Interest: None declared.

Figures

Figure 1
Figure 1
CD34 stained blood vessels in chronic periodontitis with diabetes mellitus patient (yellow arrows represent blood vessels and not all blood vessels are marked). Green arrows represent individual cells stained brown with CD34, possibly representing endothelial progenitor cells or hematopoietic stem cells. These cells were not counted (×40)
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. Little JW, Fallace DA, Miller CS, Rhodus NL. In: Dental Management of the Medically Compromised Patient. 5th ed. St. Louis: Mosby; 1997. Diabates; pp. 387–409.
    1. Karakus A, Sengun D, Berberoglu A, Caglayan G, Usubutun A, Etikan L, et al. The immunohistological comparison of the number of gingival blood vessels between type 2 diabetes mellitus and chronic periodontitis patients. Hacettepe Dishekimligi Fakultesi Dergisi Cilt. 2007;31:52–60.
    1. Stahl SS, Witkin GJ, Scopp IW. Degenerative vascular changes observed in selected gingival specimens. Oral Surg Oral Med Oral Pathol. 1962;15:1495–504. - PubMed
    1. Russell BG. Gingival changes in diabetes mellitus. 1. Vascular changes. Acta Pathol Microbiol Scand. 1966;68:161–8. - PubMed
    1. Loos BG, Craandijk J, Hoek FJ, Wertheim-van Dillen PM, van der Velden U. Elevation of systemic markers related to cardiovascular diseases in the peripheral blood of periodontitis patients. J Periodontol. 2000;71:1528–34. - PubMed