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. 2015 Mar-Apr;19(2):182-7.
doi: 10.4103/0972-124X.145817.

A randomised clinical study to measure the anti-erosion benefits of a stannous-containing sodium fluoride dentifrice

Affiliations

A randomised clinical study to measure the anti-erosion benefits of a stannous-containing sodium fluoride dentifrice

Nicola West et al. J Indian Soc Periodontol. 2015 Mar-Apr.

Abstract

Background: To compare the enamel protection efficacy of stannous-containing sodium fluoride and sodium monofluorophosphate (MFP)/triclosan dentifrices marketed in India in an in situ erosion model with acidic challenge.

Materials and methods: This randomised and controlled, in situ, supervised, double-blind clinical trial employed a two-treatment, four-period crossover design, wherein subjects wore an appliance fitted with human enamel samples 6 h/day during each 10 day treatment period and swished twice daily with their assigned dentifrice slurry: Oral-B(®) Pro-Health (maximum 1,000 ppm F as sodium fluoride with stannous chloride) or Colgate(®) Strong Teeth with Cavity Protection (maximum 1,000 F as sodium MFP and triclosan). Subjects swished with 250 ml of orange juice over a 10 min period after each treatment and twice daily for the acidic erosive challenge. Enamel samples were measured for tooth surface loss using contact profilometry at baseline and day 10.

Results: A total of 34 subjects were randomised to treatment; 32 subjects completed the final visit. Baseline profilometry measurements of the specimen surfaces were near zero within ± 0.3 μm, and no statistically significant difference (P > 0.48) on average was observed between the two test dentifrices. At day 10, the stannous-containing dentifrice demonstrated 88% less erosion (P < 0.0001) relative to the MFP/triclosan dentifrice. Estimated medians (95% confidence intervals) were 0.21 μm (0.17, 0.25) for the stannous-containing dentifrice versus 1.66 μm (1.39, 1.99) for the MFP/triclosan dentifrice. Both dentifrices were well-tolerated.

Conclusions: Compared with MFP/triclosan toothpaste, a stabilised stannous-containing sodium fluoride dentifrice gave statistically significantly greater protection against tooth enamel surface loss in situ following repeated acid erosive challenge.

Keywords: Dentifrice; erosion; sodium fluoride; stannous fluoride; triclosan.

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Conflict of interest statement

Conflict of Interest: Drs. He and Barker are employees of the Procter and Gamble Company.

Figures

Figure 1
Figure 1
Study procedures – treatment days 1–10
Figure 2
Figure 2
Contact Surface Profilomter
Figure 3
Figure 3
Enamel Loss (μm) at Day 10 versus Dentifrice displaying Period
Figure 4
Figure 4
Log Enamel Loss at Day 10 versus Dentifrice displaying Period

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