Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2015 Apr;32(2):123-6.
doi: 10.5114/pdia.2014.44003. Epub 2015 Mar 30.

Genetic background of skin barrier dysfunction in the pathogenesis of psoriasis vulgaris

Marta Stawczyk-Macieja  1 , Aneta Szczerkowska-Dobosz  1 , Krzysztof Rębała  2 , Dorota Purzycka-Bohdan  1
Affiliations
Review

Genetic background of skin barrier dysfunction in the pathogenesis of psoriasis vulgaris

Marta Stawczyk-Macieja et al. Postepy Dermatol Alergol. 2015 Apr.

Abstract

Psoriasis is a common inflammatory skin disease. It is known to be a complex condition with multifactorial mode of inheritance, however the associations between particular pathogenic pathways remain unclear. A novel report on the pathogenesis of psoriasis has recently included the genetic determination of the skin barrier dysfunction. In this paper, we focus on specific genetic variants associated with formation of the epidermal barrier and their role in the complex pathogenesis of the disease.

Keywords: epidermal differentiation complex; late cornified envelope; psoriasis.

PubMed Disclaimer

Figures

Figure 1
Figure 1
Epidermal differentiation complex
See this image and copyright information in PMC

References

    1. Griffiths CE, Barker JN. Pathogenesis and clinical features of psoriasis. Lancet. 2007;370:263–71. - PubMed
    1. Capon F, Munro M, Barker J, et al. Searching for the major histocompatibility complex psoriasis susceptibility gene. J Invest Dermatol. 2002;118:745–51. - PubMed
    1. Nair RP, Stuart PE, Nistor I, et al. Sequence and haplotype analysis supports HLA-C as the psoriasis susceptibility 1 gene. Am J Hum Genet. 2006;78:827–51. - PMC - PubMed
    1. Shabgah AG, Fattahi E, Shahneh FZ. Interleukin-17 in human inflammatory diseases. Postep Derm Alergol. 2014;31:256–61. - PMC - PubMed
    1. Candi E, Schmidt R, Melino G. The cornified envelope: a model of cell death in the skin. Nat Rev Mol Cell Biol. 2005;6:328–40. - PubMed