The role of MRI in active surveillance for prostate cancer
- PMID: 26017850
- PMCID: PMC6364669
- DOI: 10.1007/s11934-015-0507-9
The role of MRI in active surveillance for prostate cancer
Abstract
Approximately one in seven American men will be diagnosed with prostate cancer during his lifetime, and at least 50% of newly diagnosed patients will present with low-risk disease. In the last decade, the decision-making paradigm for management has shifted due to high rates of disease detection and overtreatment, attributed to prostate-specific antigen screening, with more men deferring definitive treatment for active surveillance. The advent of multiparametric magnetic resonance imaging (MP-MRI) and MRI/ transrectal ultrasound-guided fusion-guided prostate biopsy has refined the process of diagnosis, identifying patients with clinically-significant cancer and larger disease burden who would most likely benefit from intervention. In parallel, the utilization of MP-MRI in the surveillance of low-grade, low-volume disease is on the rise, reflecting support in a growing body of literature. The aim of this review is to appraise and summarize the data evaluating the role of magnetic resonance imaging in active surveillance for prostate cancer.
References
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- Final Recommendation Statement: Prostate Cancer: Screening—US Preventive Services Task Force. http://www.uspreventiveservicestaskforce.org/Page/Document/Recommendatio.... Accessed December 15, 2014.
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- Da Rosa MR, Milot L, Sugar L, et al. A prospective comparison of MRI-US fused targeted biopsy versus systemic ultrasound-guided biopsy for detecting clinically significant prostate cancer in patients on active surveillance. J Magn Reson Imaging 2014. doi:10.1002/jmri.24710. - DOI - PubMed
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Prospective trial evaluating the ability of fusion biopsy to detect clinically significant diease and the predictive value of MRI utilizing established thresholds of Gleason ≥7, and Gleason 6 >50%.
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